Table 1.
A comparison of various surveillance modalities used for detecting colorectal dysplasia in patients with IBD.
| Study | Year | IBD Type |
Type of Endoscopy |
Number of Patients | Patients with Dysplasia, n (%) |
Number of Dysplasia |
Number of CRC Patients |
p Value | Withdrawal Time (Minutes) |
|---|---|---|---|---|---|---|---|---|---|
| Subramanian et al. [130] | 2008–2010 | IBD | SD-WLE HD-WLE |
160 (UC101/CD59) 209 (UC147/CD62) |
8 (5.00) 24 (11.48) |
11 (HGD1) 32 (HGD2) |
2 5 |
0.03 | - - |
| Marion et al. [131] | 2005–2011 | IBD | SD-WLE CE |
68 (UC55/CD13) | 11 (16.18) 27 (39.71) |
11 27 |
- - |
0.001 | - - |
| Yang et al. [134] | 2013–2015 | UC | HD-WLE HD-CE |
108 102 |
6 (5.56) 4 (3.92) |
- - |
- - |
0.749 | 17.6 16.5 |
| Alexandersson et al. [133] | 2011–2016 | IBD | HD-WLE HD-CE |
153 (UC90/CD62/Indeterminate colitis1) 152 (UC96/CD54/Indeterminate colitis2) |
7 (4.58) 17 (11.18) |
7 (LGD5/HGD2) 24 (LGD21/HGD3) |
0 0 |
0.032 | 17 ± 8 24 ± 11 |
| Bisschops et al. [136] | 2008–2013 | UC | CE NBI |
66 65 |
14 (21.21) 14 (21.54) |
30 (LGD30) 20 (LGD19/HGD1) |
0 1 |
0.964 | 27.0 18.5 |
| Iacucci et al. [137] | 2014–2016 | IBD | HD-WLE CE i-SCAN |
90 (UC42/CD44/ Indeterminate colitis4) 90 (UC43/CD47/ Indeterminate colitis0) 90 (UC44/CD45/ Indeterminate colitis1) |
23 (25.56) 22 (24.44) 14 (15.56) |
22 (LGD22) 15 (LGD15) 11 (LGD11) |
0 1 0 |
0.84 | 15.4 16.2 15.3 |
| Vleugels et al. [139] | 2013–2017 | UC | CE AFI |
105 105 |
20 (19.05) 13 (12.38) |
37 (36LGD/1HGD) 14 (14LGD) |
1 0 |
0.18 | 25.1 18.0 |
| Kiesslich et al. [142] | - | UC | SD-WLE CLE |
73 80 |
4 (5.48) 11 (13.75) |
4 (3LGD/1HGD) 19 (12LGD/7HGD) |
0 0 |
0.097 | - - |
| Leong et al. [149] | 2014–2015 | IBD | FVC FUSE |
27 (UC15/CD12) 25 (UC14/CD11) |
2 6 |
7 19 |
0 0 |
0.018 | 12.0 15.8 |
IBD: inflammatory bowel disease, UC: ulcerative colitis, CD: Crohn’s disease, HD-WLE: high-definition white-light endoscopy, SD-WLE: standard-definition white-light endoscopy, CE: chromoendoscopy, NBI: narrow band imaging, AFI: autofluorescence imaging, CLE: confocal laser endomicroscopy, FVC: forward-viewing colonoscopy, LGD: low-grade dysplasia, HGD: high-grade dysplasia.