Table 3.
Disease Condition | Drug Combination | Phase | Participants | Status | NCT Number |
---|---|---|---|---|---|
Breast cancer | AST-301[pNGVL3-hICD (DNA vaccine against HER2)], rhuGM-CSF, Pembrolizumab Adagloxad simolenin, OBI-821 (Vaccine with tumor-associated antigen Globo H linked to KLH). |
II III |
146 668 |
Recruiting Recruiting |
NCT05163223 NCT03562637 |
Cervical cancer | Recombinant Human Papillomavirus Bivalent Vaccine, Recombinant Human Papillomavirus Nonavalent Vaccine, Diphtheria Toxoid/Tetanus Toxoid/Acellular Pertussis Vaccine Cecolin® (bivalent HPV vaccine) Gardasil® (HPV 9-valent Vaccine) Gardasil-9 (9-valent HPV Vaccination) |
IV III III |
5000 1025 1220 |
Enrolling by invitation Active, not recruiting Not yet recruiting |
NCT05237947 NCT04508309 NCT03848039 |
Colorectal cancer | GRT-C901, GRT-R902[Chimpanzee adenovirus vector (ChAdV)twenty tumor-specific neoantigens (TSNAs)], Atezolizumab, Ipilimumab, Fluoropyrimidine, Bevacizumab, Oxaliplatin | II/III | 665 | Recruiting | NCT05141721 |
Bladder cancer | Bacillus Calmette-Guérin (BCG) Bacillus Calmette Guerin (BCG), PF-06801591(anti-PD1 mAb) |
III III |
32 1160 |
Active not yet recruiting Recruiting |
NCT04806178 NCT04165317 |
Liver cancer | GP96 (Heat Shock Protein-Peptide Complex Vaccine) | II/III | 80 | Not yet Recruiting | NCT04206254 |
Acute myeloid leukemia | DSP-7888 [vaccine with two synthetic peptides derived from Wilms’ tumor 1 (WT1) | II | 100 | Recruiting | NCT04747002 |
Non-small cell lung cancer | UCPVax [vaccine with two peptides from hTERT], Nivolumab | II | 111 | Recruiting | NCT04263051 |
Glioblastoma multiforme | ADCTA-SSI-G1 (Autologous Dendritic Cell/Tumor Antigen) | III | 118 | Recruiting | NCT04277221 |