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Down-regulation of COPS5 diminished the speed of cell proliferation and migration. Validation of the COPS5 knockdown efficiency (A). Effects of COPS5 silencing on the colony formation ability (B,E). Knockdown of COPS5 in platinum-resistant A2780 cells led to cell-cycle arrest (C). The bar graph shows the percentages of each cell cycle phase(F). Images of the Transwell assay (400×) and quantification of the Transwell assay (D,G).
