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COPS5 silencing sensitized ovarian cancer to platinum in vivo. The tumor growth of mice injected with shCOPS5 ovarian cancer cell line was significantly reduced (A–C). HE staining showed that the ability of shCOPS5 tumor cells to invade the surrounding tissue was significantly abrogated, 200× (D). IHC staining showed that the proliferation ability of shCOPS5 tumor cells was inhibited, 200× (E,F).
