Figure 1.

DNA damage repair pathways and transcriptional activity during meiotic progression during spermatogenesis. During early prophase, double-strand breaks (DSBs) are repaired through homologous recombination (HR), and non-homologous end-joining (NHEJ) is suppressed. The localization of HR repair factors decreases, while NHEJ factors start to appear during later prophase. At the onset of meiosis, meiotic gene transcription is activated by STRA8/MEIOSIN, and then transcriptional activity is suppressed until a transcriptional burst is brought about by MYB proto-oncogene like 1 (MYBL1; also known as A-MYB) during the late pachytene stage.