Table 5.
The summary of miRNA–target gene pairs with opposite expression correlation of associated miRNA and target genes. The only pairs which showed “Experimental evidence” or “High prediction” in IPA analysis were selected. The corresponding columns also list pairs which were predicted as “Strong Target”, “Moderate Target”, and “Weak Target”. * All the miRNA-gene pairs which showed “Experimental evidence” in IPA were predicted as “Strong Target” in mintRULS. For detailed information, Supplementary Table S1 can be referred to. IPA: Ingenuity Pathway Analysis, mintRULS predictions (Strong Target: upper quartile, >75th percentile; Moderate Target: middle quartile, >25th percentile and <75th percentile; Weak Target: lower quartile, <25th percentile), STAD: stomach adenocarcinoma, CHOL: cholangiocarcinoma, ESCA: esophageal carcinoma, LIHC: liver hepatocellular carcinoma. Upward red arrow: upregulation, downward green arrow: down regulation.
| Cancer Type | Expression | IPA | mintRULS | ||||||
|---|---|---|---|---|---|---|---|---|---|
| miRNA | Target Gene | Exp. Observed* | High Predicted | Total | Strong-Target | Moderate-Target | Weak-Target | Total | |
| STAD |
|
|
13 | 77 | 90 | 28 | 46 | 16 | 90 |
|
|
15 | 11 | 26 | 16 | 9 | 1 | 26 | |
| CHOL |
|
|
21 | 134 | 155 | 71 | 64 | 20 | 155 |
|
|
80 | 169 | 249 | 125 | 101 | 23 | 249 | |
| ESCA |
|
|
36 | 20 | 56 | 29 | 21 | 6 | 56 |
|
|
4 | 20 | 24 | 14 | 8 | 2 | 24 | |
| LIHC |
|
|
3 | 4 | 7 | 7 | 0 | 0 | 7 |
|
|
23 | 19 | 42 | 42 | 0 | 0 | 42 | |