Figure 2.

Genetic abnormality aggregation in patients with transposition of the great arteries. Global interaction of anomalies found in patients (a) The shared colors represent the clustering according to the Markov algorithm. Ciliary genetic anomalies are observed in genes involved in diverse processes such as ciliogenesis, ciliary trafficking, and the function of motile cilia. Individual patient aggregation of missense, nonsense, frameshift, and splicing deleterious variants is observed (b). In both, the line thickness indicates the strength of data support and the confidence of interactions; the thinnest line represents low confidence (0.150), next, medium confidence (0.400); then, high confidence (0.700), and, finally, the thickest line is the highest value (0.900). EPV. Enrichment p-value.