Table 1.

IL-17 cytokine family producing cells, targets, and effector molecules.

Cytokine	Cellular Sources	Target Cells	Downstream Effector Molecules	References
IL-17A	Th17, Tc17, TRM, γδT, iNKT, neutrophils, MAIT, ILC3	Mesenchymal cells, myeloid cells, macrophages, epithelial cells, keratinocytes, intestinal and nasal epithelial cells, B cells, CD4+ T cells	G-CSF, MIP2, IL-8, MCP-1, IL-1β, TNFα, IL-6, Il-10, IL-2, PGE2, hBD-2, β-defensin, S100A9, S100A8, S100A7, calprotectin, lipocalin, MMP-9	[46,72,94,96,104,115,126,127,128,132,134,135,136,137,138,139,140]
IL-17B	Neutrophils, chondrocytes, neurons, stromal cells, gut epithelium, B cells (germinal and memory)	ILC2, NKT, THP-1 monocytes, fibroblasts, Th2, PBMC, ILC2	IL-5, IL-13, G-CSF, IL-6, CCL20, TNFα, IL-1β	[3,87,124,143,144,145,146,147,148]
IL-17C	Epithelial cells	Epithelial cells, Th17	G-CSF, IL-6, IL-1β, TNFα, AMPs, occluding, claudin-1, claudin-4	[64,66,124,151,152,153,155,156,157]
IL-17D	Fibroblasts, colonic epithelial cells, brain, skeletal muscle, adipose tissue, heart, lung, pancreas	Endothelial cells, ILC3	IL-22, RegIIIβ/γ, MCP-1, IL-8, IL-6, GM-CSF	[7,34,67,159,160]
IL-17E (IL-25)	Mast cells, alveolar macrophages, eosinophils, basophils, ILC2, dendritic cells, stromal cell, epithelial cells, Th2	Keratinocytes, lung epithelial cells, endothelial cells, Th2, Th9, macrophages, fibroblasts, ILC2, DCs	Keratin 6, keratin 16, keratin 17, IL-1β, IL-9, IL-4, IL-5, IL-6, IL-13, TNFα	[47,68,85,86,124,161,162,163,164,165,166,167,172,173]
IL-17F	Th17, LTi, NK, iNKT, neutrophils, ILC3, γδT	Epithelial cells, endothelial cells, stromal cells, eosinophils, fibroblasts, macrophages, primary keratinocytes	CXCL1, G-CSF, GM-CSF, ICAM-1, IL-6, IL-8, IL-1β, CXCL, hBD-2, S100A7, S100A8, S100A9	[4,12,21,48,109,110,111,114,115,116,141,142]
IL-17A/F	Th17, γδT, iNKT, NKp46+	Epithelial cells, fibroblasts	CXCL1, IL-6, IL-8	[18,23,117]