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. 2022 Sep 13;8(5):2268–2284. doi: 10.3390/tomography8050190

Table 4.

Global associations with pAO2 measures.

pAO2 Mean pAO2 SD pAO2 %Negative
Exposure N β (95% CI) p β (95% CI) p β (95% CI) p
%emphysema −950 HU
Unadjusted 54 −0.0007 (−0.002, 0.0005) 0.26 0.002 (0.0009, 0.003) 0.0002 * 0.57 (0.29, 0.86) 0.0002 *
Model 1 54 −0.0003 (−0.002, 0.0009) 0.62 0.001 (0.0003, 0.002) 0.005 * 0.37 (0.11, 0.63) 0.007 *
Model 2 53 −0.0001 (−0.001, 0.001) 0.85 0.001 (0.0003, 0.002) 0.006 * 0.32 (0.05, 0.60) 0.02 *
Visual emphysema severity (%) 1
Unadjusted 50 −0.0002 (−0.001, 0.0006) 0.64 0.0008 (0.0002, 0.001) 0.01 * 0.29 (0.10, 0.48) 0.004 *
Model 1 50 −0.00005 (−0.0008, 0.0007) 0.90 0.0005 (0.0001, 0.001) 0.02 * 0.22 (0.05, 0.38) 0.01 *
Model 2 49 0.00006 (−0.0008, 0.0009) 0.89 0.0005 (0.00003, 0.001) 0.04 * 0.19 (0.01, 0.36) 0.04 *
ADC 2
Unadjusted 50 −0.0005 (−0.001, 0.0002) 0.17 0.0008 (0.0003, 0.001) 0.003 * 0.36 (0.12, 0.61) 0.004 *
Model 1 50 −0.0004 (−0.001, 0.0004) 0.33 0.0007 (0.0002, 0.001) 0.005 * 0.30 (0.08, 0.53) 0.01 *
Model 2 49 −0.0002 (−0.001, 0.0006) 0.63 0.0006 (0.0002, 0.001) 0.01 * 0.24 (0.02, 0.47) 0.04 *
DLCO
Unadjusted 34 −0.0003 (−0.002, 0.001) 0.65 0.001 (0.0003, 0.002) 0.007 * 0.23 (0.05, 0.41) 0.01 *
Model 1 34 −0.0001 (−0.002, 0.002) 0.93 −0.001 (−0.002, −0.00003) 0.04 * −0.22 (−0.46, 0.01) 0.06
Model 2 34 −0.0001 (−0.002, 0.002) 0.91 −0.001 (−0.002, −0.00004) 0.04 * −0.22 (−0.45, 0.01) 0.06

1 Calculated as the sum of the severity scores for centrilobular, panlobular, and paraseptal emphysema. 2 Per 0.01 change. * p-value < 0.05. ADC, apparent diffusion coefficient; HU, Hounsfield units; pAO2, partial pressure of oxygen; SD, standard deviation. Unadjusted: (weighted). Model 1: adjusted for age, sex, race/ethnicity, cigarette smoking status (weighted). Model 2: Model 1 + %-predicted FEV1 (weighted). Generalized linear models were used, and participants were weighted on the inverse ratio of probability of selection.