TABLE 2.
Impact of natural compounds affecting significant stem pathways cell signaling (Angulo et al., 2017).
| Major paths for signaling | Components | Objective | Effect | References |
|---|---|---|---|---|
| Notch | Curcumin | The notch-1 and downstream genes Hes-1, Hey-1, and Hey-2 mRNA speed downregulate transcriptions and translations. | Causes apoptosis by increasing reactive species of oxygen. | Tu et al. (2012) |
| Diallyl trisulfide | Intracellular domain targets Notch-1 | Decreases downstream gene expression of Notch. Enhances expression of microRNAs (miR143 and miR-145) possible tumor suppressants and reduces tumor support for miR-21 MicroRNA. | Tutelyan and Lashneva, (2013) | |
| WNT/β-catenin | Resveratrol | histone H2AX; β-catenin | Apoptosis in ROS cells triggers telomere instability and DNA disruption by lowering -catenin mRNA and protein expression and c-Myc Histone H2AX phosphorylation. | Angulo et al. (2017) |
| Hedgehog | Cyclopamine | SMO-binding | Signal transduction to GLIS is prevented. | Kumar and Fuchs, (2015) |
| PI3/AKT | Sulforaphane | AKT and ERK | It suppresses phosphorylation of ERK and AKT and induces apoptosis by arresting cells in the G2/M process. | Aggarwal et al. (2007) |