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. 2022 Sep 1;8(9):554. doi: 10.3390/gels8090554

Table 1.

Characteristics of ultrasound-responsive hydrogels for tissue engineering applications.

Application Hydrogel Polymer System Payload Ultrasound Parameters Reference
Bone
Regeneration
Alginate
Hydrogel
BMP-2 2.5 min/h for 5 h
Amplitude of 25%
9.6 mW/cm2
[106]
Cartilage Repair Chitosan
Hydrogel
BMSCs aided by nanocarriers 1 MHz
2–3 W/cm2
20–30% duty cycle
[72]
Bone
Regeneration
Alginate
Hydrogel
BMP-2 conjugated gold nanoparticles 2.5 min/h for 5 h
Amplitude of 25%
9.6 mW/cm2
[93]
Cartilage
Repair
Chitosan
Hydrogel
Kartogenin on
microparticles
2 and 5 min intervals [115]
Skin Repair Cellulose
Hydrogel Film
Mimosa drug LIFU 23, 43, and 96 kHz
5–30 W
[116]
Vascularization Fibrin Hydrogel bFGF release 100 Hz, 6.1 MPa
5.4 μs pulse
[117]
Bone
Regeneration
Collagen
Hydrogel
Osteoblasts LIPUS 1 MHz, 1 kHz, 1 Hz
Duty cycle: 20%, 50% or 100%
30 and 150 mW/cm2
[65]