Figure 6.

γH2AX foci vs. CTCAE grades. The number of pATM foci per cell assessed 10 min (A) or 1 h (B) post-irradiation from 200 COPERNIC cell lines was plotted against the corresponding CTCAE grade values (closed circles). Each point corresponds to the mean ± standard error of the mean (SEM) of 3 independent triplicates, at least. (C) The maximal number of pATM foci per cell among the 10 min and 1h data shown in panels (A,B) was plotted against the corresponding CTCAE grade values (closed circles). The best data fit was obtained with the linear law: pATMmax (grade) = 41.72 − 6.78 × grade (r² = 0.74) (dotted line). The points corresponding to the ATM- (open circles) and the LIG4- (open triangles) mutated cell lines are indicated.