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. 2022 Sep 9;23(18):10434. doi: 10.3390/ijms231810434

Figure 7.

Figure 7

SF2 vs. pATMmax, pATmax vs. MN24h and pATMmax vs. H2AX24h relationships. (A) The SF2 data from 36 COPERNIC cell lines were plotted against the corresponding number of γH2AX foci per cell assessed 24 h post-irradiation (closed circles). Each point corresponds to the mean ± standard error of the mean (SEM) of three independent triplicates, at least. The best data fit was obtained with the linear law: SF2 (pATMmax) = 1.422 × pATMmax; r2 = 0.87 (dotted line). (B) The pATMmax from 200 COPERNIC cells were plotted against the corresponding number of micronuclei assessed 24 h post-irradiation (B) or the corresponding number of micronuclei assessed 24 h post-irradiation (C) Each point corresponds to the mean ± standard error of the mean (SEM) of three independent triplicates, at least. The grey square indicates all the AT data if considering γH2AX foci in ATM-mutated cells as absent. The points corresponding to the ATM- (open circles) and the LIG4- (open triangles) mutated cell lines are indicated.