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. 2022 Sep 6;23(18):10223. doi: 10.3390/ijms231810223

Figure 2.

Figure 2

Involvement of AEPs in Alzheimer and other neurological diseases. Aging and ischemia upregulate AEPs in the brain, probably through activation of C/EBPβ or other transcriptional regulation mechanisms (?). The cleavable substrates of AEPs include SET, tau, APP, α-synuclein, TDP-43, and TLR7/9. Upregulated AEPs contribute to the pathogenesis of Alzheimer’s disease (AD), and may participate in the progression of Parkinson’s disease (PD), traumatic brain injury (TBI), frontotemporal lobar degeneration (FTLD), stroke, and neuroinflammation.