AD	Alzheimer’s disease
AEP	asparaginyl endopeptidase
LGMN	legumain
APP	amyloid precursor proteins
Aβ	amyloid-β protein
Asn	asparagine
Asp	asparate
TLRs	toll-like receptors
APCs	Ag-presenting cells
ER	endoplasmic reticulum
LSAM	Legumain stabilization and activity modulation
MBP	myelin basic protein
PD	Parkinson’s disease
VD	vascular dementia (VD)
FTLD	frontotemporal lobar degeneration (FTLD)
DLB	dementia with Lewy bodies
APOE4	apolipoprotein E4
NFTs	neurofibrillary tangles
SET	an inhibitor of protein phosphatase 2A
PP2A	protein phosphatase 2A
C/EBPβ	CCAAT/enhancer binding protein β
FSH	follicle-stimulating hormone
MCI	mild cognitive impairment
CSF	cerebrospinal fluid
P-tau	phosphorylated tau
PET	positron-emission tomography
BBB	blood–brain barrier
AuNPs	gold nanoparticles
CT	computerized tomography
MRI	magnetic resonance imaging
TBI	traumatic brain injury
tMCAO	transient occlusion of the middle cerebral artery
OGD	the oxygen–glucose deprivation
Ca2+	calcium
TDP-43	TAR DNA-binding protein 43
GBM	glioblastoma