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. 2022 Sep 8;23(18):10392. doi: 10.3390/ijms231810392

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(a) Preparation of different TFP-F1 derivatives. TFP-F1R was prepared by treating the TFP-F1 with the CMC and NaBH₄, while deOAc TFP-F1 was afforded by treating TFP-F1R with NaOH. TFP-F1P was the product of the periodate cleavage of TFP-F1. (b) The level of TNF-α was stimulated in the J774A.1 macrophage cells induced by the treatment of TFP-F1 of TFP-F1P. (c) The level of TNF-α secreted in the J774A.1 macrophage cells by the treatment of TFP-F1, TFP-F1R, and deOAc TFP-F1R.