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. 2022 Sep 6;23(18):10209. doi: 10.3390/ijms231810209

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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HNRNP A1 inhibits the senescence of hepatocellular carcinoma through the cells’ cell cycle mediated by P16^INK4. (A) The expression levels of the SASP in HCC cell lines, LO2; (B) the change of the expression levels of the SASP after knocking down of HNRNP A1; (C) the expression of KI-67 after knocking down of HNRNP A1; (D,E) the expression of GLB-1 and representative images of SA-β-gal staining in HCC cells with the knockdown of HNRNP A1 and the control group; (F) the expression of P16^INK4 after knocking down of HNRNP A1 detected by Western blot; (G) promotion of the levels of P16INK4 upon treatment with 8 µM of VPC-80051 in LM3 cells and 16 µM of VPC-80051 in LI7 cells; (H,I) effects of the HNRNP A1 and P16^INK4 difference in the cell cycle distribution of HCC cells. * p < 0.05; ** p < 0.01; *** p < 0.001; **** p < 0.001. The data are expressed as the mean ± SD.