Table 2.

The host proteins regulating the ZBP1 signaling.

Host Regulatory Factors	Positive(P) or Negative(N) Regulation	Regulatory Mechanisms	Reference(s)
AIM2	P	Interacts with ZBP1 to drive PANoptosis	[84]
TRIM34	P	Induces the K63-linked polyubiquitination of ZBP1 on the K17 position	[116]
CASP6	P	Strengthens ZBP1–RIPK3 interactions	[119]
PUMA	P	Promotes the cytoplasmic release of mtDNA and activation of ZBP1	[164]
ADAR1	N	Inhibits the ZBP1 sensing for activated Z-RNA	[33,160,161,162,163]
RIPK1	N	Disrupts ZBP1–RIPK3 interactions	[149,150]
SETDB1	N	Holds down the level of ERV-derived dsRNA and activation of ZBP1	[155]
tRF3-Thr-AGT	N	Degrades the mRNA of ZBP1	[170]