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. 2022 Sep 7;23(18):10319. doi: 10.3390/ijms231810319

Figure 2.

Figure 2

PAs inhibit NFκB-dependent gene transcription. The NFκB-dependent luciferase activity was quantified 2 h post-stimulation of NFκB-MDA-MB-231-nanoluc cells. Compounds (1)–(6) were applied at a concentration ranging from 1000 nM to 0.06 nM before being stimulated for 2 h with 20 ng/mL TNFα. In each individual experiment, the NFκB-dependent luminescence was normalized to the lowest concentration applied (100%). Each data point represents the mean of at least three independent experiments.