Table 1.
IC50-values determined for NFκB inhibition and reduction of cell viability.
| NFκB Inhibition | Reduction of Cell Viability |
||
|---|---|---|---|
| Compound |
2 h 1
IC50 [nM] 4 |
24 h 2
IC50 [nM] 4 |
24 h 3
IC50 [nM] 4,5,6 |
| (1) | 17.1 ± 2.0 | 3.7 ± 1 | 13.6 ± 0.4 5 |
| (2) | 211.8 ± 69.9 | 38.2 ± 14.2 | 117.9 ± 35.0 4 |
| (3) | 284.9 ± 60.4 | 114.5 ± 17.9 | 55.3 ± 13.2 4 |
| (4) | 83.0 ± 14.7 | 28.3 ± 5.6 | 127 ± 21.4 4 |
| (5) | >1000 | >1000 | >1000 6 |
| (6) | >1000 | >1000 | >1000 6 |
| Paclitaxel | >1000 | >1000 | 37.4 ± 8.6 4 |
NFκB inhibition was tested after 1 2-h or 2 24-h treatment with the NFκB inhibition assay. 3 Cell viability was determined 24 h post-treatment with the 2D cell viability assay. 4 Mean ± SD (n ≥ 3). 5 Mean ± SD (n = 2). 6 Mean ± SD (n = 1).