Figure 3.

Photothermal response of nanoparticles and non-encapsulated materials and DOX release quantification. Representative radiometrically-measured changes in temperature rise of various agents in isotonic PBS in response to 808 nm pulsed (0.5 s) laser irradiation at radiant exposures of (A) D_o = 50 J/cm² and (B) D_o = 90 J/cm² are shown. Legends in panel (A) also correspond to traces shown in panel (B). (C) Average values of the maximum temperature rise. (D) Percentage of ICG absorbance value retained following irradiation. (E) Mean percentage of DOX released from IDNETs and F-IDNETs in the dark (without laser irradiation) in response to acidic pH 5.5 and in response to 0.5 s laser irradiation at D_o = 25 J/cm² in nearly neutral pH 7.6. Error bars in panels (C,E) represent SDs from the mean.