Figure 1.

The effect of MI on the heart/tibia ratio and ANP protein levels in the heart in the WT, SCD1^−/−, and SCD4^−/− mice. (A) The heart/tibia ratio (mg/mm) was measured to analyze cardiac hypertrophy in mice that were sacrificed 7 days post-MI. (B) The protein levels of ANP in the sham and post-MI myocardium were determined by Western blot. Some of the variability in ANP expression after myocardial infarction is likely related to the variable number of fibroblast cells, which infiltrated the infarct scar, therefore, in the infarcted hearts, some areas could have higher/lower the ANP content. The data are representative of n = 5 mice/group. The data are expressed as mean ± SD. * p < 0.05, vs. WT sham; ^# p < 0.05, vs. SCD1^−/− sham; ^& p < 0.05, vs. SCD4^−/− sham (two-sided t-test).