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Cryo-EM of PI3Kα-nanobody complexes shows previously unreported features. (A) Nb3-126 leads to a high-resolution cryo-EM electron density map as illustrated by a representative α-helix, residues 808 to 826 of p110α. (B) Nb3-142 has stabilized extra density as compared with other cryo-EM data. (C and D) Nb3-159 has an altered position of the ABD and iSH2 domains in comparison with other PI3Kα structures.
