Table 3.

The synergies in cancer multicomponent therapy.

No.	Therapeutically Active Agents	In Vitro/In Vivo Activity	Cancer Type	Effect	Ref.
1	Bleomycin and tea polyphenols	In vitro (SiHa cells)	Cervical cancer	Reduced cancer cells viability, reduced proliferation, increased apoptosis	[78]
2	Ibuprofen and EGCG	In vitro (DU-145)	Prostate cancer	Better growth inhibition, reduced proliferation, increased apoptosis	[81]
3	Dasatinib and curcumin	In vitro (HCT-116) and in vivo (APCMin+/− mice)	Colon cancer	Increased inhibition of numerous metastatic processes, improved cell adhesion phenotype of HCT-116 colon cancer cells, regression of intestinal adenomas of 95%, reduced tumor progression, and improved apoptosis	[85]
4	Pterostilbene and EGCG	In vitro (MIA PaCa-2 and PANC-1)	Pancreatic cancer	Cell cycle arrest in S-phase in the case of MIA PaCa-2 cells, but not in PANC-1 cells, stimulated mitochondria depolarization and cytochrome-C upregulation in MIA PaCa-2 cells, but not in PANC-1 cells, enhanced antitumoral effects	[86]
5	Resveratrol and 5-fluorouracil	In vitro (TE-1 and A431) and in vivo (melanoma model)	Skin and esophageal cancer	Important tumor regression rate after four weeks of treatment, enhanced percentage of apoptotic cells and caspase-3, p53 and cleaved PARP levels, blocking cancer cells growth and induction of apoptosis	[97]