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. 2022 Sep 6;23(18):10206. doi: 10.3390/ijms231810206

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Immunohistochemical analysis of the retina from CAG-HtrA1 Tg mice vs. wild-type control (17 months). (A) Hematoxylin and eosin staining of the whole retina of CAG-HtrA1 Tg shows the flecked structures (yellow arrows) in the RPE layer denoting the presence of RPE migration in the retina. (B) RPE migration reflected in the OCT corresponding to the H&E stains (C,D) showing expression of ApoE (yellow arrows) in the RPE and CD31 in the retina and the choroid (red arrows) confirming that there is no significant difference between the CAG-HtrA1 Tg mice and wild-type mice groups. (F) Ki67, proliferation marker was not detected in CAG-HtrA1 Tg mice. (E) VEGFR2 and (G) Recoverin showed positive. Nuclei were stained with DAPI (blue). (Abbreviations: RNFL: retinal nerve fibre layer; GCL: ganglion cell layer; IPL: inner plexiform layer; INL: inner nuclear layer; OPL: outer plexiform layer; ONL: outer nuclear layer; IS/OS: inner and outer segment; and RPE: retinal pigment epithelium).