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. 2022 Sep 6;23(18):10257. doi: 10.3390/ijms231810257

Figure 4.

Figure 4

Quantification of cell viability of hMSC after administration of modafinil (11.2 µg/mL) for 24 h (A), 48 h (B), 72 h (C), atomoxetine (0.9 µg/mL) for 24 h (D), 48 h (E), 72 h (F) and guanfacine (17.7 ng/mL) for 24 h (G), 48 h (H), 72 h (I). Briefly, 10% DMSO was added to hMSC as a positive indicator of cell toxicity. Column height represents the metabolic capacity of hMSC to reduce resazurin into resorufin, which is fluorescent. Values are given as mean ± standard deviation to blank of three independent experiments with six biological replicates. Significance in difference between untreated, 10% DMSO-, modafinil-, atomoxetine- and guanfacine treated hMSC was determined by ANOVA followed by Tukey’s post hoc tests. * corresponds to a value of p < 0.05. *** corresponds to a value of p < 0.001.