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. 2022 Sep 6;23(18):10261. doi: 10.3390/ijms231810261

Figure 7.

Figure 7

In TGFβ1-activated colon fibroblasts, ZNF281 controlled the expression of collagens COL4A1 and COL1A1 and COL4A1 secretion. Expression of COL4A1 and COL1A1 mRNAs was assessed by RT-qPCR in siCtl, siCtl TGFβ1, siZNF281, and siZNF281 TGFβ1 CCD-18Co (A). COL4A1 secretion was analyzed in cell supernatants by Western blot and normalized on total secreted proteins. Densitometric analysis was performed (B). Data are expressed as mean ± SEM. * = p-value ≤ 0.05; ** = p-value ≤ 0.01; *** = p-value ≤ 0.001; n = 3.