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. 2022 Sep 15;2022:2198923. doi: 10.1155/2022/2198923

Figure 1.

Figure 1

UCA1 is a human-specific lncRNA that is upregulated in preeclampsia. (a) Evolutionary analysis of UCA1 sequences from the UCSC database. (b) The expression level of UCA1 in villous tissues derived from the first trimester and term labor was analyzed using qRT-PCR (n =20). (c) Differential expression analysis of publicly available RNA sequencing data from primary trophoblast cells and stromal cells. (d) Differential expression analysis of GSE75010, including preeclamptic placental tissues (n =80) and normal controls (n =77). (e–f) The RNA levels of UCA1 (e) and HIF1α (f) in placental tissues derived from normotensive controls and patients with preeclampsia were analyzed using qRT-PCR (n =30). (g) Representative images and statistical analyses of WB showed that HIF1α was increased in the preeclamptic placenta. Statistical results were calculated from three independent experiments (n =4). ∗∗P < 0.01, ∗∗∗P < 0.001, and ∗∗∗∗P < 0.0001. CTB, cytotrophoblast; EVT, extravillous trophoblast; STB, syncytiotrophoblast; PE, preeclampsia.