Table 1. Obstetric and gynecological uses of mifepristone.

FDA: Food and Drug Administration; LNG: levonorgestrel; DMPA: depot medroxyprogesterone acetate; LH: luteinizing hormone; IVF: in vitro fertilization

Obstetric and gynecological uses	Indications	Recommended doses
FDA-approved use
1	Early pregnancy termination	Mifepristone 200 mg orally on day 1, misoprostol 800 µg buccally after 24-48 hours
Proposed uses
1	Second-trimester termination of pregnancy	Mifepristone 200 mg orally, followed by misoprostol 200 μg vaginally 3 hourly [15]
2	Missed abortion and fetal demise	600 mg/day for 2 days [19]; 200 mg orally with misoprostol (14-28 weeks of gestation) [20]
3	Menstrual induction	Mifepristone 600 mg single dose [22]; mifepristone 150 mg, misoprostol 0.4 mg vaginally after 2 days [24]
4	Emergency contraception	Less than 25 mg single dose [29]; 25-50 mg single dose [29]
5	Estrogen-free contraceptive pill	2 and 5 mg daily [30]; 25 mg once weekly [36]; 200 mg once a month on the 16th day of the menstrual cycle [35]
6	Cervical dilatation	600 mg orally single dose [39]
7	Induction of labor	200 mg single dose [42]
8	Ectopic pregnancy	Methotrexate 50 mg/m2 intramuscularly and mifepristone 600 mg orally [44,45]
9	Endometriosis	50 and 100 mg daily for 6 months [46]; 50 mg for 6 months [47]
10	Leiomyomas	10-25 mg daily for 3 months [55]
11	Adenomyosis	5 mg daily [60]
12	Breakthrough bleeding in LNG and DMPA	50 mg every 2 weeks for 24 weeks [61]; 100 mg every 30 days for 3 months [63]
13	Premature LH surges undergoing controlled ovarian hyperstimulation in IVF	2.5 mg two doses after follicle aspiration [66]; 40 mg daily [67]