Extended Data Fig. 1. 6-Month rDBS outcomes.

Bilateral stimulation has been well tolerated by both subjects (~1.5μC/cm² charge density, 10 s duration). Both subjects report an increased sense of control specific to food cravings and eating-related behaviors. Here, behavior outcomes are reported at 6-months with stimulation (rDBS) compared to pre-surgery baseline. A) For both subjects, LOC frequency decreased with stimulation (Subject 1: 16-point decrease; Subject 2: 13-point decrease). B) With LOC episode severity, both subjects showed decrease in severity from baseline to 6-months with stimulation (Subject 1: Baseline = 1.84 + /−0.69 (n = 13 samples), 6-month = 0.69 + /−0.053 (n = 13 samples), student’s t-test, p = 0.05; Subject 2: Baseline = 0.84 + /−0.15 (n = 13 samples), 6-month = 0.15 + /−.09 (n = 13 samples), student’s t-test, p = 0.09). Further, both subjects also experienced decreases in C) For both subjects, Objective Binge Eating events (OBE) decreased with stimulation (Subject 1: 8-point decrease; Subject 2: 12-point decrease). D) Weight (kg, %) and E) BMI (Subject 1: Weight = −5.9 kg, 4.5%, BMI = −2.2; Subject 2: Weight = −8.2 kg, 5.8%, BMI = −2.9). Bar graphs with error bars are presented as mean band power + /- S.E.