Fig. 3. Drivers and determinants of FMT community-level outcomes.

a, Ex ante predictability of microbial community-wide outcomes for individual FMTs (summarized across all trackable strain populations in a triad of donor, recipient pre-FMT and recipient post-FMT samples; Fig. 2) using cross-validated LASSO linear models with regularized subsets of different variable categories or a combination of all variables (‘full’ model) knowable before the intervention (Methods and Supplementary Table 6). Within each category, only the most relevant predictors are included. Predictive performance for each outcome index is shown as R² on the left, and variable importance and directionality for the most predictive factors as cross-validated LASSO coefficients on the right. b, Association of FMT outcomes with LASSO-regularized sets of post hoc variables (measured after the intervention).