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. 2022 Sep 12;4(9):1150–1165. doi: 10.1038/s42255-022-00629-2

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 6 — a, Violin-plots showing the distribution of missing data (as percentage of the total) among individuals’ genotypes, stratified by UPV groups. This data show that the degree of genome wide missingness is not correlated to UPV groups. b, Table summarizing the amount of genetically identical loci among MZ cotwins and genetic differences, only due to missing data. c, Barplot summarizing the data in table b. MZ cotwins were identical on > 99.9% of the analyzed loci and differences due to missing data account on average for ~ 0.06% of the total data, among all UPV groups. d, Heatmaps showing the distribution of SNPs that resulted different between MZ cotwins, only due to missing data. On the left, the cotwin pairs are ordered by the UPV sub-types. On the right, they are ordered according to hierarchical clustering. These data show that neither the degree of missingness, nor the specific genomic positions of missing data showed any correlation to UPV sub-types. e, Same as in a, on the indicated genesets. These data show no specific enrichment of missingness in any UPV group, nor any genesets, arguing against evidence for genotypic differences underlying the detected transcriptional signatures. All p-values as assessed by ANOVA.