Table 2.
Demographics and baseline characteristics (All Population Propensity Score-Matched)
| Parameters | Abaloparatide (N = 11,616) |
Teriparatide (N = 11,616) |
Standardized difference |
|---|---|---|---|
| Age (years)ab | |||
| N | 11,616 | 11,616 | 0.023 |
| Mean (SD) | 67.3 (8.36) | 67.5 (8.35) | |
| Median | 67.0 | 67.0 | |
| Interquartile range | 61.0, 74.0 | 61.0, 75.0 | |
| Min, max | 50, 80 | 50, 80 | |
| Age group (years), n (%)a | |||
| 50–64 | 4779 (41.1) | 4599 (39.6) | 0.032 |
| 65–74 | 3961 (34.1) | 4053 (34.9) | 0.017 |
| ≥ 75 | 2876 (24.8) | 2964 (25.5) | 0.017 |
| Race/ethnicity, n (%)b | |||
| African American | 152 (1.3) | 151 (1.3) | 0.001 |
| Asian | 104 (0.9) | 98 (0.8) | 0.006 |
| White | 4368 (37.6) | 4505 (38.8) | 0.024 |
| Hispanic | 682 (5.9) | 551 (4.7) | 0.050 |
| Other | 140 (1.2) | 122 (1.1) | 0.015 |
| Unknown | 6170 (53.1) | 6189 (53.3) | 0.003 |
| Osteoporosis disease history | |||
| Diagnosed osteoporosis prior index date, n (%) | 7508 (64.6) | 7451 (64.1) | 0.010 |
| Years since 1st diagnosis in 5 years pre-index date | |||
| N | 7508 | 7451 | 0.002 |
| Mean (SD) | 2.8 (2.2) | 2.8 (2.2) | |
| Median | 2.6 | 2.6 | |
| Interquartile range | 0.5, 4.9 | 0.5, 4.9 | |
| Min, max | 0.0, 7.1 | 0.0, 7.1 | |
| Fracture at any time pre-index, n (%) | 2968 (25.6) | 2973 (25.6) | 0.001 |
| Fracture in the year prior to index date, n (%) | 1876 (16.2) | 1863 (16.0) | 0.003 |
| GI disorders, n (%) | 4465 (38.4) | 4467 (38.5) | 0.000 |
| Fall risk conditions, n (%)c | 8413 (72.4) | 8561 (73.7) | 0.029 |
| Any cardiovascular risk factor, n (%)d | 8910 (76.7) | 8948 (77.0) | 0.008 |
| Prior osteoporosis medication, n (%) | |||
| Alendronate | 3131 (27.0) | 3212 (27.7) | 0.016 |
| Ibandronate | 859 (7.4) | 840 (7.2) | 0.006 |
| Risedronate | 723 (6.2) | 725 (6.2) | 0.001 |
| Zoledronic acid | 418 (3.6) | 402 (3.5) | 0.007 |
| Denosumab | 1269 (10.9) | 1215 (10.5) | 0.015 |
| Hormone replacement therapy, n (%) | 2837 (24.4) | 2797 (24.1) | 0.008 |
| Oral glucocorticoids, n (%) | |||
| Any prior or current exposure | 7328 (63.1) | 7352 (63.3) | 0.004 |
| Current usee | 754 (6.5) | 777 (6.7) | 0.008 |
GI, gastrointestinal; HIPAA, Health Insurance Portability and Accountability Act; max, maximum; min, minimum; SD, standard deviation
aDue to HIPAA, age over 80 is recorded as 80. Age is matched at the group level (50–64, 65–74, 75 +)
bVariables are not included in the propensity score matching covariates
cIncludes stroke, history of falls, mobility issues, visual impairment, hearing impairment, Parkinson’s Disease, Alzheimer’s Disease, muscle weakness, atrophy, obesity, rehabilitation, dementia, depression, anxiety, and sleep disorders
dIncludes diagnosis of cardiovascular disease identified by the following terms: cardiac, coronary, pulmonary, cerebrovascular, peripheral arterial, vasculitis, venous, and hypertension; and cardiovascular risk factors: hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, type II diabetes, obesity
eCurrent use is 30 days before or after index date