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. 2022 Jun 8;45(5):2078–2090. doi: 10.1007/s10753-022-01677-2

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — Dapagliflozin decreased the percentage of M1 and increased the percentage of M2 in myocardium at day8 after CVB3 infection. a Immunofluorescent double staining of myocardial tissue with antibodies to CD68 and CD163. Red indicates CD68 (one marker for M1), green CD163 (one marker for M2), and blue DAPI-stained cellular nuclei. b, c Quantitative reverse transcription polymerase chain reaction (qRT-PCR) was used to detect iNOS and CD206 mRNA levels. Data were expressed as mean ± SD (control, normal mice; Dapa, normal mice treated with dapagliflozin; CVB3, CVB3-infected mice treated with 60% propylene glycol; CVB3 + Dapa, CVB3-infected mice treated with dapagliflozin. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001).