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. 2022 Sep 22;13(9):813. doi: 10.1038/s41419-022-05215-8

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Principle description of the work procedure used to study the “IL-17A/CTSK” axis in CRPC. The expression profiles data of various types of prostate cancer (#GSE70770, GSE32982 and GSE32269). B Heatmap of 23 up-regulated genes and 85 down-regulated genes mined from GSE70770, GSE32982 and GSE32269. The lower bar shows different groups, the pink one represents the group of CRPC and the orange red one represents the group of localized PC. C The bar chart shows KEGG pathway enrichment data for DEGs. Pink represents up-regulated pathways and blue represents down-regulated pathways. D Circle diagram was adopted for further exploration to clarify the expression genes involved in the three significantly up-regulated pathways. E Estimate the therapeutic values of CTSK by analyzing the ROC curve (p < 0.001).