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. 2022 Sep 22;13:5552. doi: 10.1038/s41467-022-33284-y

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Neutralizations of the CoV2-06-resistant SARS-CoV-2 virus with K444R mutation (a) and CoV2-14-resistant SARS-CoV-2 virus with E484A mutation (b) by indicated bispecific antibodies and the antibody cocktail of CoV2-06 and CoV2-14. The assay is based on the mNeonGreen reporter virus and the NT₅₀ values are labeled. c Plaque reduction neutralization test (PRNT) of 14-H-06 against the SARS-CoV-2 US-WA1 strain and recombinant SARS-CoV-2 viruses with the spike replaced by those from indicated variants. The values of neutralizing titers (NT₅₀) are labeled. d Neutralizations of the Omicron variant by indicated bispecific antibodies, the antibody cocktail of CoV2-06 and CoV2-14 and two parental antibodies. The assay is based on the mNeonGreen reporter virus and the NT₅₀ values are labeled. Data are from two replicates. e Summary of the ELISA binding EC₅₀ values of indicated antibodies to the wild type RBD and a panel of 20 RBD mutants. f The violin plot of the EC₅₀ values in d. The Kruskal-Wallis test was used for statistical analysis.