Table 2.
Estimates (growth of geographic atrophy [GA] per year in mm) for all parameters included in the best fit model for GA progression.
| Parameter | Estimate | P-value | Lower 95% CI | Upper 95% CI |
|---|---|---|---|---|
| FAF Pattern (focal)a | 0.243 | 0.019* | 0.04 | 0.446 |
| FAF Pattern (banded)a | 0.319 | 0.004* | 0.104 | 0.534 |
| FAF Pattern (diffuse)a | 0.4 | <0.001* | 0.209 | 0.591 |
| FAF Pattern (diffuse-trickling)a | 0.89 | <0.001* | 0.611 | 1.169 |
| HRF concentration | 13.336 | 0.01 | 5.465 | 21.208 |
| HRF*FAF Pattern (focal)a | −13.258 | 0.008* | −23.001 | −3.511 |
| HRF*FAF Pattern (banded)a | −10.412 | 0.08 | −22.089 | 1.265 |
| HRF*FAF Pattern (diffuse)a | −12.285 | 0.01* | −21.534 | −3.035 |
| HRF*FAF Pattern (diffuse-trickling)a | −17.458 | <0.001* | −26.881 | −8.036 |
| SDD presence (yes) | 0.102 | 0.005* | 0.031 | 0.173 |
| Age(visit)*sqrt GA area | −0.001 | 0.001* | −0.001 | 0 |
| Fellow eye (MNV)b | −0.112 | 0.678 | −0.641 | 0.417 |
| Fellow eye (GA)b | 0.096 | 0.701 | −0.396 | 0.589 |
| Fellow eye (GA + MNV)b | 0.001 | 0.996 | −0.535 | 0.538 |
FAF fundus autofluorescence, HRF hyperreflective foci, MNV macular neovascularization, GA geographic atrophy, iAMD intermediate age-related macular degeneration, SDD subretinal drusenoid deposits, sqrt square root, CI confidence interval.
*Statistical significance p ≤ 0.05.
aCompared to FAF Pattern (none).
bCompared to iAMD.