Figure 7.

Metabolic pathways with higher-than-average mRNA-protein correlations may reflect differential reproducibility

Bar charts displaying the KEGG pathway enrichment analysis of the CCLE mRNA-protein correlation before (left) and after (right) accounting for protein-protein and mRNA-mRNA reproducibility. The −log₁₀ of Benjamini-Hochberg false discovery rate (FDR)-corrected p values calculated using Mann-Whitney U test is used to assess enrichment for the pathway. For each bar chart, the gray line indicates the threshold considered for significant enrichment (FDR < 0.05). If the enrichment is below the threshold, then it is not considered significant. The bars are colored orange if the median mRNA-protein correlation of genes within the pathway is greater than the median mRNA-protein correlation of genes not in the pathway; otherwise, the bars are colored blue.