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. 2022 Sep 8;2(9):100287. doi: 10.1016/j.crmeth.2022.100287

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This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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CM-treated MCMV immunization is safe

(A) A histology image of the liver section from control mice. The images were acquired at 10× magnification. Cells, nuclei, and other structures are intact without any cytotoxicity.

(B) A histology image of the liver section from CM-treated MCMV immunized mice. The cells and nuclei can be seen intact without any cell toxicity. The images were acquired at 10× magnification.

(C) Cell viability of ARPE-19, MRC-5, and 3T3 cells incubated with CM-treated viruses after washing of unbound CM. No significant difference was observed in the viability of cells after incubation with CM-treated virus immunogens. After washing, most of the unbound CM is removed, and a minute amount of CM remains bound to the virus genomic DNA. This residual CM is present in small amounts and has many fewer genotoxic effects. p >0.05 compared with uninfected cells.