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. 2022 Sep 9;13:969924. doi: 10.3389/fendo.2022.969924

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Copyright © 2022 López-Soldado, Guinovart and Duran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Liver PTG overexpression decreases body weight and food intake in db/db mice. (A) Relative mRNA of PTG in the liver, (B) Liver glycogen content, (C) Growth curve from 6-18 weeks of age, (D) Fat weight, (E) Lean weight, and (F) Daily food intake of db/db and db/db-PTG mice, and non-diabetic controls (n=6-12 in all experiments except food intake n=18-26). All values are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001. For figure (A) Diabetes factor (F ratio=4.090, P=0.0540), PTG factor (F ratio=123.5, P<0.0001), Interaction (F ratio=1.963, P=0.1734). For figure (B) Diabetes factor (F ratio=20.81, P<0.0001), PTG factor (F ratio=243.8, P<0.0001), Interaction (F ratio=3.354, P=0.0777). For figure (C) 6 weeks of age Diabetes factor (F ratio=43.79, P<0.0001), PTG factor (F ratio=2.250, P=0.1456), Interaction (F ratio=5.106, P=0.0325). For figure (C) 8 weeks of age Diabetes factor (F ratio=119.5, P<0.0001), PTG factor (F ratio=3.982, P=0.0566), Interaction (F ratio=8.517, P=0.0072). For figure (C) 10 weeks of age Diabetes factor (F ratio=175.3, P<0.0001), PTG factor (F ratio=8.286, P=0.0079), Interaction (F ratio=8.461, P=0.0073). For figure (C) 12 weeks of age Diabetes factor (F ratio=327.4, P<0.0001), PTG factor (F ratio=19.51, P=0.0002), Interaction (F ratio=20.02, P=0.0001). For figure (C) 14 weeks of age Diabetes factor (F ratio=467.6, P<0.0001), PTG factor (F ratio=94.71, P=0.0004), Interaction (F ratio=13.08, P=0.0013). For figure (C) 16 weeks of age Diabetes factor (F ratio=529.7, P<0.0001), PTG factor (F ratio=20.50, P=0.0001), Interaction (F ratio=15.65, P=0.0005). For figure (C) 18 weeks of age Diabetes factor (F ratio=442.1, P<0.0001), PTG factor (F ratio=9.595, P=0.0046), Interaction (F ratio=7.617, P=0.0105). For figure (D) Diabetes factor (F ratio=1620, P<0.0001), PTG factor (F ratio=11.46, P=0.0017), Interaction (F ratio=14.32, P=0.0005). For figure (E) Diabetes factor (F ratio=62.29, P<0.0001), PTG factor (F ratio=0.4716, P=0.4964), Interaction (F ratio=6.722, P=0.0134). For figure (F) Diabetes factor (F ratio=128.8, P<0.0001), PTG factor (F ratio=13.47, P=0.0004), Interaction (F ratio=15.02, P=0.0002).