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. 2022 Sep 9;13:969924. doi: 10.3389/fendo.2022.969924

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Copyright © 2022 López-Soldado, Guinovart and Duran

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Hepatic overexpression of PTG reverts hyperglycemia in db/db mice. (A) Blood glucose, (B) Plasma insulin, (C) GTT curve for glucose, (D) AUC for glucose in the GTT, (E) ITT curve for glucose, and (F) ITT curve for glucose expressed as the percentage of initial values for db/db and db/db-PTG mice, and non-diabetic controls (n=6-14 in all experiments). All values are mean ± SEM. *P<0.05, **P<0.01, ***P<0.001. For figure (A) Diabetes factor (F ratio=7.195, P=0.0118), PTG factor (F ratio=7.150, P=0.0110), Interaction (F ratio=7.002, P=0.0118). For figure (B) Diabetes factor (F ratio=57.71, P<0.0001), PTG factor (F ratio=1.594, P=0.2135), Interaction (F ratio=0.9109, P=0.3452). For figure (C) time 0, Diabetes factor (F ratio=18.06, P=0.0002), PTG factor (F ratio=2.654, P=0.1149), Interaction (F ratio=5.059, P=0.0329). For figure (C) time 15, Diabetes factor (F ratio=40.23, P<0.0001), PTG factor (F ratio=14.31, P=0.0008), Interaction (F ratio=3.444, P=0.0744). For figure (C) time 30, Diabetes factor (F ratio=20.27, P=0.0001), PTG factor (F ratio=17.46, P=0.0003), Interaction (F ratio=0.1980, P=0.6599). For figure (C) time 60, Diabetes factor (F ratio=34.92, P<0.0001), PTG factor (F ratio=12.84, P=0.0013), Interaction (F ratio=0.08646, P=0.7710). For figure (C) time 120, Diabetes factor (F ratio=22.24, P<0.0001), PTG factor (F ratio=4.044, P=0.0544), Interaction (F ratio=0.3171, P=0.5780). For figure (D) Diabetes factor (F ratio=34.95, P<0.0001), PTG factor (F ratio=12.59, P=0.0014), Interaction (F ratio=0.5225, P=0.4760). For figure (E) time 0, Diabetes factor (F ratio=37.17, P<0.0001), PTG factor (F ratio=6.741, P=0.0153), Interaction (F ratio=2.575, P=0.1090). For figure (E) time 15, Diabetes factor (F ratio=36,54, P<0.0001), PTG factor (F ratio=4.318, P=0.0477), Interaction (F ratio=3.019, P=0.0941). For figure (E) time 30, Diabetes factor (F ratio=37.52, P<0.0001), PTG factor (F ratio=3.314, P=0.0802), Interaction (F ratio=3.768, P=0.0632). For figure (E) time 60, Diabetes factor (F ratio=71.07, P<0.0001), PTG factor (F ratio=4.625, P=0.0410), Interaction (F ratio=7.297, P=0.0120).