TABLE 1.

List of main alteration of metabolites/composition in drug induced liver injury.

References	Drug	Alter of metabolites/composition
Clayton et al. (113)	Acetaminophen	β-glucuronidase/Firmicutes, Bacteroides
Gong et al. (37)	Acetaminophen	1-phenyl-1,2-propanedione/Escherichia coli, Citrobacter freundii
Yildirim et al. (114)	Neomycin, ampicillin, metronidazole	Enterobacteriales, anaerobic bacteria, Clostridiales phylum
Miao et al. (60)	Scutellarein	Enterococcus
Sun et al. (115)	Antithyroid	Prevotellaceae_UCG-003, Oscillibacter, Rikenellaceae_RC9
Zheng et al. (12)	Acetaminophen	P-cresol/Clostridium difficile
Yip et al. (59)	Tacrine	β-glucuronidase/Lactobacillus, Bacteroides, Enterobacteriaceae
Xia et al. (34)	Acetaminophen	SCFA/Oscillibacter, Colidextribacter, Mucispirillum
Yin et al. (116)	D-galactosamine	Proteobacteria, Blautia, Romboutsia, Parabacteroides, UCG-008, Parasutterella, Ruminococcus, norank_f: Lachnospiraceae, Eubacterium_xylanophilum, Oscillibacter, Eisenbergiella.