Table 1.
Patient characteristics.
| Cohort A, N (%) | Cohort B, N (%) | Cohort C, N (%) | |
|---|---|---|---|
| Sex | |||
| Female | 14 (70) | 10 (38) | 30 (73) |
| Male | 6 (30) | 16 (62) | 11 (27) |
| Mean age at diagnosis in years | 70.5 | 72 | 72.1 |
| Smoking history | |||
| Never smoker | 17 (85) | 7 (27) | 30 (73) |
| Light ex-smoker (<15 pack-year) | 3 (15) | 0 | 6 (15) |
| Former | 0 | 9 (35) | 3 (7) |
| Current | 0 | 10 (38) | 2 (5) |
| Final histological diagnosis | |||
| Adenocarcinoma | 12 (60) | 22 (85) | 39 (95) |
| Squamous cell | 0 | 2 (8) | 0 |
| NSCLC NOS | 0 | 1 (4) | 2 (5) |
| Large cell carcinoma | 1 (5) | 1 (4) | 0 |
| LCNEC | 1 (5) | 0 | 0 |
| Lymphoepithelioma-like | 1 (5) | 0 | 0 |
| Carcinoid | 1 (5) | 0 | 0 |
| Sarcomatoid | 1 (5) | 0 | 0 |
| Not lung primary a | 2 (10) | 0 | 0 |
| Unknown b | 1 (5) | 0 | 0 |
a
One patient was diagnosed with lung metastases from gastric adenocarcinoma, one patient with diffuse large-B lymphoma (JAK2, IDH1 gene alterations).
b
One patient underwent ctDNA plasma testing and CT-guided liver biopsy both negative for malignancy.
CT, computed tomography; ctDNA, circulating-tumor DNA; LCNEC, large cell neuroendocrine carcinoma; NSCLC, non-small cell lung cancer: NOS, not otherwise specified.