Figure 3.

CMA and oxidative stress in diseases. CMA plays a protective or pathogenic role in different diseases by counteracting oxidative stress. CMA protects organisms against aging, neurodegeneration, liver disease, and infection. However, CMA also promotes the development of cancers. The picture above shows the mechanisms of CMA in specific diseases.

Abbreviations: CMA, chaperone-mediated autophagy; MEF2D, myocyte-specific enhancer factor 2D; PARK7, parkinsonism associated deglycase; MARCHF5, membrane-associated ring-CH-type finger 5; SNCA, alpha-synuclein; APP, amyloid-beta precursor protein; TRIM21, tripartite motif containing 21; HIF-1α, hypoxia-inducible factor 1-alpha.