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. 2022 Sep 9;13:996965. doi: 10.3389/fpsyt.2022.996965

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Copyright © 2022 Castelli, Plescia, Maniaci, Lavanco, Pizzolanti, Brancato and Cannizzaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Anxiety-like phenotype and stress reactivity in the rat model of binge-like alcohol exposure. Alcohol binge drinking during adolescence was modeled in rats in order to assess anxiety-like phenotype and stress reactivity (A). Altered anxiety-like phenotype and stress reactivity in the rat model of binge-like alcohol exposure. Rats exposed to binge-like alcohol during adolescence displayed a higher integrated z-score referring both to anxiety-like behavior under social or novel circumstances than CTRL rats (B). When the active coping to the swim stress was evaluated as a measure of resilience, BAW rats displayed a lower score than the CTRL group (C). Moreover, binge-like alcohol exposure altered the neuroendocrine stress response in adolescent rats. In detail, when CTRL rats were exposed to social stress, they displayed increased CORT serum levels, with respect to basal levels; on the other hand, no significant increase was observed in BAW rats (D). Data are shown as the mean ± SEM. *p < 0.05; ***p < 0.001. CTRL, control group; BAW, binge-like alcohol-exposed rats; SI, social interaction test; NSFT, novelty suppressed feeding test; FST, forced swimming test; CORT, corticosterone.