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. 2022 Jul 1;14(4):925–944. doi: 10.1016/j.jcmgh.2022.06.008

Figure 1.

Figure 1

HNE is involved in the progression of disease in NASH.A, Semi-quantitative assessment of HNE immunoreactivity in the liver tissue of patients with NAFLD. The density of HNE immunoreactivity was scored into 3 grades as follows: no staining (Grade 0), weak and uniform staining of the entire tissue specimen (Grade 1), and intense spots (arrows) with uniform staining (Grade 2). The rectangle is magnified. B, HNE immunostaining in human liver tissue. The rectangle in the middle and its magnified image in the right, show focal HNE immunorecativity in the liver of a patient with NAFLD. C, The degree of HNE deposition was compared between patients with nonfatty liver (n = 13) and patients with NAFLD (n = 90). D, Relationships between pathological scores and HNE staining grades 0 (n = 6), 1 (n = 47), and 2 (n = 37) in patients with NAFLD. Lobular inf, lobular inflammation; Mattenoni, Matteoni’s classification; NAS, NAFLD activity score.