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. 2022 Sep 9;12:980620. doi: 10.3389/fonc.2022.980620

Figure 1.

Figure 1

Crosstalk between ferroptosis and immunosuppression and inflammation in PMN. The ingredients that promote the formation of PMN include TDSFs, EVs, MDSCs, M2-like TAMs, tBregs, Tregs and N2-like neutrophils. The components that inhibit the formation of PMN include IFNγ, DC cells, NK cells, M1-like TAMs, N1-like neutrophils and CD8+ T cells. The ingredients that promote ferroptosis include RSL3, erastin, gemcitabine, sulfasalazine, cisplatin, IFNγ, ACSL4 and arachidonic acid. The components that inhibit ferroptosis include GPX4 and system xc-. ACSL4, acyl-CoA synthetase long-chain family member 4; ASAH2, N-acylsphingosine amidohydrolase 2; DAMPs, damage-associated molecular patterns; DC cells, dendritic cells; EVs, extracellular vesicles; FINs, ferroptosis inducers; GPX4, glutathione peroxidase 4; HMGB1, high mobility group box 1 protein; IFNγ, interferon γ; MDSCs, myeloid-derived suppressor cells; NK cells, natural killer cells; NRF2, nuclear factor E2-related factor 2; PBMCs, Peripheral blood mononuclear cells; PMN, pre-metastatic niche; TAMs, tumor-associated macrophages; tBregs, tumor-evoked regulatory B cells; TDSFs, tumor-derived secreted factors; Tregs, regulatory T cells.