TABLE 3.
Univariate and multivariate analyses of the prognostic factors for progression-free survival.
| Factors | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P | HR | 95% CI | P | |
| Age (≥60 vs. < 60), year | 1.282 | 0.693–2.370 | 0.429 | — | — | — |
| Gender (male vs. female) | 0.606 | 0.275–1.335 | 0.214 | — | — | — |
| Etiology (HBV vs. NBNC) | 0.386 | 0.202–0.735 | 0.004 | 0.192 | 0.088–0.418 | 0.001 |
| Tumor size (≥5 vs. < 5), cm | 1.304 | 0.703–2.422 | 0.400 | — | — | — |
| AFP level (≥400 vs. < 400), ng/ml | 2.418 | 1.236–4.733 | 0.010 | 2.893 | 1.233–6.787 | 0.015 |
| ECOG PS (0–1 vs. 2) | 1.121 | 0.594–2.115 | 0.724 | — | — | — |
| Child–Pugh class (A vs. B) | 1.183 | 0.574–2.439 | 0.648 | |||
| BCLC stage (B vs. C) | 1.057 | 0.540–2.070 | 0.870 | — | — | — |
| Vascular invasion (yes vs. no) | 2.889 | 1.528–5.461 | 0.001 | 3.158 | 1.436–6.942 | 0.004 |
| Extrahepatic metastasis (yes vs. no) | 0.703 | 0.372–1.326 | 0.276 | |||
| Cirrhosis (yes vs. no) | 0.562 | 0.255–1.241 | 0.154 | |||
HBV, hepatitis B virus; NBNC, non-HBV, non-HCV; AFP, a-fetoprotein; ECOG PS, eastern cooperative oncology group performance status.