The estimated risk of clinical events was calculated from multivariable-adjusted, mixed-effects Cox proportional hazards regression, accounting for age, sex, hypertension, diabetes mellitus, hypercholesterolemia, and clinical diagnosis. Blue dotted lines represent optimal cutoff values for TVF (0.86) and cardiac death or TVMI (0.80) at 2 years. FFR indicates fractional flow reserve; PCI, percutaneous coronary intervention; TVF, target vessel failure; TVMI, target vessel myocardial infarction.