Table. Risk of Clinical Events at 2 Years per Post-PCI FFR 0.01 Decrease.
| Event | Total events, No. (%)a | HR (95% CI) | P value | Adjusted HR (95% CI)b | P value | τ2 |
|---|---|---|---|---|---|---|
| Target vessel failure | 340/5204 (7.2) | 1.034 (1.019-1.049) | <.001 | 1.035 (1.020-1.051) | <.001 | <0.001 |
| Cardiac death or TVMI | 111/5204 (2.4) | 1.035 (1.002-1.068) | .04 | 1.034 (1.001-1.068) | .049 | <0.001 |
| Cardiac death | 64/5274 (1.4) | 1.047 (1.013-1.083) | .006 | 1.045 (1.011-1.081) | .009 | 0.001 |
| TVMI | 57/5207 (1.2) | 1.018 (0.973-1.066) | .44 | 1.018 (0.973-1.066) | .44 | 0.001 |
| TVR | 285/5276 (6.0) | 1.033 (1.016-1.051) | <.001 | 1.034 (1.015-1.052) | <.001 | <0.001 |
Abbreviations: FFR, fractional flow reserve; HR, hazard ratio; PCI, percutaneous coronary intervention; TVMI, target vessel myocardial infarction; TVR, target vessel revascularization.
a
The cumulative incidence of clinical outcomes at 2 years is presented as Kaplan-Meier estimates.
b
The following patient risk factors were included in the multivariable-adjusted mixed-effects Cox proportional hazard regression model: age, sex, hypertension, diabetes, hypercholesterolemia, and acute coronary syndrome.